山姆（汤姆·加瓦那 Tom Cavanagh 饰）和格瑞（海瑟·格拉汉姆 Heather Graham 饰）是一对关系十分要好的兄妹，两人不仅住在一起，而且还有这相同的爱好。可惜的是，这一段和谐的关系被一个叫做查理（布丽姬·穆娜 Bridget Moynahan 饰）的女人给生生打破了。山姆和查理的关系以一种非常迅速的形式顺利发展着，很快便到了谈婚论嫁的地步，而此时格瑞才发现，对于哥哥的准未婚妻，自己竟然心存非分之想。 困扰的格瑞向各方人马发出了求救信号，但每一个人的回答都无法令她感到满意。对于格瑞来说，自己的面前只剩下一条路可走，那就是赶紧着把自己给嫁出去。在得知了格瑞的这一想法后，她的好友格蒂（艾伦·卡明 Alan Cumming 饰）决定助她一臂之力。Gray and Sam are brother and sister and best friends, flatmates in New York City, where she creates ad campaigns and he's a surgery intern. Their social life is too insular, so they head to a dog park so Sam can, maybe, meet a woman. He does - Charlie - a zoologist new in the city; he likes her immediately, and the feeling seems mutual. As the three of them spend time together, what if Gray's feelings for Charlie aren't just sisterly? Not only might this explain her solitary life, but it could lead to real dilemmas - with Charlie (who's sweet, but a bit opaque) and with Sam. No advice comes from Gray's therapist, but a co-worker and a cab driver give theirs. Can Gray sort things out?
