在欧洲乡间的秘密研究室里, 一位顶尖的科学家正对着两只巨蟒进行实验测试. 当资助者(约翰莱斯戴维斯饰) 企图干预实验时, 饥饿的蟒蛇逃出了研究室. 汉密特(戴维赫索霍夫饰) 受雇追捕牠们, 其任务是必须在蟒蛇窜逃到城市且在灾难扩大以前, 实时捉拿这多产又极度致命的生物……Cancer-terminal tycoon Peter Murdoch's secret Wexel Hall Pharmaceuticals lab has developed a blood orchid extract cure. To examine why it works optimally in snakes, they also bread a super-anaconda strain. But the original pair escapes, leaving a bloody trail of corpses. Murdoch runs, instructing his staff to clean up. They keep failing and being eaten like unsuspecting locals, some alive, even after enlisting ruthless big game hunter Hammett. The fast-growing pregnant monster sheds its skin, thus disabling the only tracking device.
